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Immediate changes in transcription factors and synaptic transmission in the cochlea following acoustic trauma: a gene transcriptome study
2020
Neuroscience research
Pathologic mechanisms in cochleae immediately following the onset of noise-induced hearing loss (NIHL) remain unclear. In this study, mice were exposed to 120 dB of octave band noise for 2 hours to induce NIHL. Three hours after noise exposure, expression levels of the whole mouse genome in cochleae were analyzed by RNA-seq and DNA microarray. Differentially expressed genes (DEGs) exhibiting >2-fold upregulation or downregulation in noise-exposed cochleae compared to controls without noise
doi:10.1016/j.neures.2020.05.001
pmid:32417196
fatcat:4avkppcmsbg3rljcifmzkiw7pi