Full Sequencing of the FLG Gene in Italian Patients with Atopic Eczema: Evidence of New Mutations, but Lack of an Association

Raffaella Cascella, Valeria Foti Cuzzola, Tiziana Lepre, Elena Galli, Viviana Moschese, Loredana Chini, Cinzia Mazzanti, Paola Fortugno, Giuseppe Novelli, Emiliano Giardina
2011 Journal of Investigative Dermatology  
REFERENCES Arck PC, Overall R, Spatz K et al. (2006) Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J 20:1567-9 Commo S, Gaillard O, Thibaut S et al. (2004) Absence of TRP-2 in melanogenic melanocytes of human hair. Pigment Cell Res 17:488-97 Gunn DA, Rexbye H, Griffiths CE et al. (2009) Why some women look young for their age. PLoS One 4:e8021 Michard Q, Commo S, Rocchetti J et
more » ... . (2008) TRP-2 expression protects HEK cells from dopamine-and hydroquinone-induced toxicity. Free Radic Biol Med 45:1002-10 Nishimura EK, Granter SR, Fisher DE (2005) Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307:720-4 Pawelek JM, Lerner AB (1978) 5,6-Dihydroxyindole is a melanin precursor showing potent cytotoxicity. Nature 276:626-8 Pelle E, Mammone T, Maes D et al. (2005) Keratinocytes act as a source of reactive oxygen species by transferring hydrogen peroxide to melanocytes. J Invest Dermatol 124:793-7 Reynolds A, Murray PI, Colloby PS (1998) Darkening of eyelashes in a patient treated with latanoprost. Eye (Lond) 12(Part 4):741-3 Shaffrali FC, McDonagh AJ, Messenger AG (2002) Hair darkening in porphyria cutanea tarda. Br J Dermatol 146:325-9 Slominski A, Tobin DJ, Shibahara S et al. (2004) Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 84:1155-228 Thibaut S, De Becker E, Caisey L et al. (2009) Human eyelash characterization. Br J Dermatol 162:304-10
doi:10.1038/jid.2010.398 pmid:21289640 fatcat:fpixhsmzsreypcnq5tgcexuww4