North American ginseng (Panax quinquefolius) suppresses β-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction

Xilan Tang, Xiaohong Tracey Gan, Venkatesh Rajapurohitam, Cathy Xiaoling Huang, Jenny Xue, Edmund M.K. Lui, Morris Karmazyn
2016 Canadian Journal of Physiology and Pharmacology  
Keyword: ginseng, heart failure, cardiac hypertrophy, isoproterenol, PKA/CREB https://mc06.manuscriptcentral.com/cjpp-pubs Canadian Journal of Physiology and Pharmacology r a f t North American ginseng (P. quinquefolius) suppresses β adrenergic-dependent signalling, hypertrophy and cardiac dysfunction https://mc06.manuscriptcentral.com/cjpp-pubs Canadian Journal of Physiology and Pharmacology These effects were associated with attenuation in both protein kinase A and cAMP response
more » ... g protein phosphorylation. Ginseng attenuates adverse cardiac adrenergic responses and may therefore be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production.
doi:10.1139/cjpp-2016-0337 pmid:27797280 fatcat:heib6jotebev3hifjdj7aumj44