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North American ginseng (Panax quinquefolius) suppresses β-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction

Xilan Tang, Xiaohong Tracey Gan, Venkatesh Rajapurohitam, Cathy Xiaoling Huang, Jenny Xue, Edmund M.K. Lui, Morris Karmazyn
2016 Canadian Journal of Physiology and Pharmacology  

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Keyword: ginseng, heart failure, cardiac hypertrophy, isoproterenol, PKA/CREB https://mc06.manuscriptcentral.com/cjpp-pubs Canadian Journal of Physiology and Pharmacology r a f t North American ginseng (P. quinquefolius) suppresses β adrenergic-dependent signalling, hypertrophy and cardiac dysfunction https://mc06.manuscriptcentral.com/cjpp-pubs Canadian Journal of Physiology and Pharmacology These effects were associated with attenuation in both protein kinase A and cAMP response
more » ... g protein phosphorylation. Ginseng attenuates adverse cardiac adrenergic responses and may therefore be an effective therapy to reduce hypertrophy and heart failure associated with excessive catecholamine production.
doi:10.1139/cjpp-2016-0337 pmid:27797280 fatcat:heib6jotebev3hifjdj7aumj44
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Xilan Tang, Xiaohong Tracey Gan, Venkatesh Rajapurohitam, Cathy Xiaoling Huang, Jenny Xue, Edmund M.K. Lui, Morris Karmazyn. "North American ginseng (Panax quinquefolius) suppresses β-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction." Canadian Journal of Physiology and Pharmacology 94.12 (2016) 1325-1335