A novel neutral gummi base was newly formulated and several gummi containing model drugs (carboxylic acid drug : ibuprofen and mefenamic acid, sodium carboxylate drug : loxoprofen sodium and sodium valproate) were prepared in order to compare the base and a conventional acidic gummi base using citric acid. By acidic formulation, both loxoprofen sodium and sodium valproate were found to not be able to jell into a gummi form. Furthermore, an acidic gummi base containing mefenamic acid lost its

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... formity of drug contents during the jelling process. On the other hand, a neutral formulation made it possible for gummi containing loxoprofen sodium or sodium valproate to jell into gummi form, and thereby maintained the distribution of mefenamic acid in the neutral gummi base.