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Enzyme-triggered PEGylated siRNA-nanoparticles for controlled release of siRNA
©The Authors | Journal of RNAi and Gene Silencing |
A key goal of our recent research efforts has been to develop novel 'triggerable nanoparticle' systems with real potential utility in vivo. These are designed to be stable from the point of administration until a target site of interest is reached, then triggered for the controlled release of therapeutic agent payload(s) at the target site by changes in local endogenous conditions or through the application of some exogenous stimulus. Here we describe investigations into the use of enzymes tofatcat:2og3oovsxndubjvqn6vwh5fmkm