Adrenergic Receptor Signaling Components in Gene Therapy [chapter]

Andrea D. Eckhart, Walter J. Koch
2006 The Adrenergic Receptors  
Adrenergic receptor (AR) signaling is a key regulator of normal cardiopulmonary homeostasis. Under pathophysiological conditions, such as heart failure, asthma, and hypertension, there are alterations in the signaling cascades. Advances in the ability to manipulate the adenoviral genome have allowed the development of gene therapy in which transgenes of interest are inserted into the adenovirus and transferred to mammals in an organ-specific manner based on delivery methods. These transgenes
more » ... These transgenes have included components of the AR signaling pathway that have gone awry at the level of the AR itself or the G protein it activates, the G protein-coupled receptor kinases (GRKs), and regulators of G protein signaling (RGS) proteins that regulate AR desensitization, or the adenylyl cyclase that subsequently activates protein kinase A activity. The use of these vectors in both the heart and the lung has offered promising novel benefits for animal models of disease, including heart failure and lung disorders, and it remains to be determined whether these will be successful future therapeutic strategies in human disease.
doi:10.1385/1-59259-931-1:321 fatcat:g5xkeb5xyjba3b347mrnyvlhr4