Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology

N. A. Peppas, Y. Huang, M. Torres-Lugo, J. H. Ward, J. Zhang
2000 Annual Review of Biomedical Engineering  
Key Words controlled release, diffusion, polymer network, responsive hydrogels, swelling s Abstract Hydrogels are cross-linked hydrophilic polymers that can imbibe water or biological fluids. Their biomedical and pharmaceutical applications include a very wide range of systems and processes that utilize several molecular design characteristics. This review discusses the molecular structure, dynamic behavior, and structural modifications of hydrogels as well as the various applications of these
more » ... iohydrogels. Recent advances in the preparation of three-dimensional structures with exact chain conformations, as well as tethering of functional groups, allow for the preparation of promising new hydrogels. Meanwhile, intelligent biohydrogels with pH-or temperature-sensitivity continue to be important materials in medical applications.
doi:10.1146/annurev.bioeng.2.1.9 pmid:11701505 fatcat:gmyq2xkmkfbrrn3cext34ugxy4