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Key Words controlled release, diffusion, polymer network, responsive hydrogels, swelling s Abstract Hydrogels are cross-linked hydrophilic polymers that can imbibe water or biological fluids. Their biomedical and pharmaceutical applications include a very wide range of systems and processes that utilize several molecular design characteristics. This review discusses the molecular structure, dynamic behavior, and structural modifications of hydrogels as well as the various applications of thesedoi:10.1146/annurev.bioeng.2.1.9 pmid:11701505 fatcat:gmyq2xkmkfbrrn3cext34ugxy4