Beta-antagonist and secondary hyperparathyroidism in chronic renal failure

KATSUJI TAKEDA, EIJI KUSANO, YASUSHI ASANO, SAICHI HOSODA
1985 The Japanese Journal of Nephrology  
We evaluated the acute response of parathyroid hormone (PTH) and calcitonin (CT) secretion to non-selective and beta-1 selective antagonists and studied the long -term effects of non-selective betaantagonists on calcium metabolism in chronic hemodialysis patients . Administration of exprenolol (non-selective) and metoprolol (beta-1 selective) depressed thePTH secretion similarly . Long-term administration of non-selective beta-antagonists resulted in a significant decrease in PTH , CT and alk
more » ... ine phosphatase levels without producing any changes in calcium and phosphate levels . Th ese results suggest that 1) beta-1 adrenergic receptors may play an imp ortant role in the regulation of PTH secretion, 2) the beta-adrenergic system may also play a role in the regulation of CT secretion, and 3) beta-antagonist therapy may be useful for the prevention of secondary hyperparathyroidism in chronic hemodialysis patients.
doi:10.14842/jpnjnephrol1959.27.1299 fatcat:xiemfzdgvvfrvjvd2c7b3tg64a