Acute respiratory distress syndrome is common in critically ill patients admitted to intensive care units. Simulation, the art and science of recreating a clinical scenario in an artificial setting, has been an important aspect of nursing program curriculums for decades. Aim: to determine the impact of using simulation on critical care nursing students' knowledge and skills of acute respiratory distress syndrome. Design: quasi experimental research design. Setting: critical care lab in faculty

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... f nursing at Assuit University. Methods: sixty critical care nursing students were included in this study. Acute respiratory distress syndrome assessment questioners, performance checklist about acute respiratory distress syndrome and student satisfaction questionnaire have been used. The study was carried out on four phases: assessment, preparation, implementation and evaluation. Results: There was a statistical significant difference between the control and the study group after using the simulation strategy in relation to their knowledge and clinical performance of Acute Respiratory Distress Syndrome. Conclusion: The level of critical care nursing students' knowledge and clinical performance of Acute Respiratory Distress Syndrome were general improved after application of teaching program with simulation learning strategy.