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A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells
Chinese hamster ovary (CHO) cells, with their human-compatible glycosylation and high protein titers, are the most widely used cells for producing biopharmaceuticals. Engineering gene expression in CHO is key to improving drug quality and affordability. However, engineering gene expression or activating silent genes requires accurate annotation of the underlying regulatory elements and transcription start sites (TSSs). Unfortunately, most TSSs in the Chinese hamster genome were computationallydoi:10.1101/2020.10.09.334045 fatcat:yuvaxl56ibfgnfychuj37fx4mu