Transdermal delivery constitutes one of the most important routes for novel drug delivery system. Significant resistant nature of skin is the main trouble for successful drug delivery to deep skin layers for systemic absorption. Several approaches including physical, chemical and novel formulation techniques have been explored for safe and effective drug delivery across the skin barrier. Among them, potential lipid-based carrier solid lipid nanoparticles have gained a unique position for

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... rmal delivery of drugs due to the presence of high amount of epidermal lipids as the chief component of the penetration barrier of the skin. Skin-carrier interaction involves attachment of these carriers to skin with a view to permit the exchange of lipid between the outermost layers of the stratum corneum. This review specifically focuses on the hurdles of transdermal drug delivery, the need of novel carriers for transdermal delivery with special emphasis on role of solid lipid nanoparticles suggesting this lipid carrier a potential moiety for drug delivery through the skin.