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Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy
2021
Frontiers in Cellular Neuroscience
Gliomas are the most common and lethal malignant tumor in the central nervous system. The tumor oncogene sphingosine kinase 2 (SphK2) was previously found to be upregulated in glioma tissues and enhance glioma cell epithelial-to-mesenchymal transition through the AKT/β-catenin pathway. Nevertheless, ubiquitination of SphK2 protein has yet to be well elucidated. In this study, mass spectrometry analysis was performed to identify proteins that interacted with SphK2 protein. Co-immunoprecipitation
doi:10.3389/fncel.2021.660354
fatcat:rjjpm7vh3rcilaxp2i7amghqmq