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Tissue-selective alternate promoters guide NLRP6 expression
2020
Life Science Alliance
The pryin domain (PYD) domain is involved in protein interactions that lead to assembly of immune-sensing complexes such as inflammasomes. The repertoire of PYD-containing genes expressed by a cell type arms tissues with responses against a range of stimuli. The transcriptional regulation of the PYD gene family however is incompletely understood. Alternative promoter utilization was identified as a mechanism regulating the tissue distribution of human PYD gene family members, including NLRP6
doi:10.26508/lsa.202000897
pmid:33376129
fatcat:mucehug6qfaqnadnyihmfc3yoa