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P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles
2022
Frontiers in Pharmacology
Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral deposition and inflammation. One potential link is the P2X7 purinoceptor, a key trigger of inflammation, which is expressed on macrophages but also up-regulated in dystrophic muscle cells. To investigate the role of P2X7 in dystrophic calcification, we
doi:10.3389/fphar.2022.935804
pmid:35910348
pmcid:PMC9333129
fatcat:67pugt4hmzaf7psf7equsfg4mi