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Inactivation of RAS association domain family 1A gene in cervical carcinomas and the role of human papillomavirus infection
Recently, we have identified a new putative tumor suppressor gene, RASSF1A (Ras association domain family 1A gene), located at human chromosome 3p21.3, the segment that is often lost in many types of human cancers. The RASSF1A promoter was shown to be frequently hypermethylated in various epithelial tumors, including small cell lung, breast, bladder, prostate, gastric, and renal cell carcinomas. In this study, we have analyzed the methylation status of the RASSF1A gene in primary human cervicalpmid:12702579 fatcat:s5neyz3rtvdo7j7vcdpknr4ena