Differences in the Influence of AIN-Purified and Non-purified Diets on the Development of Hypertension in SHR and DOCA-salt Hypertensive Rats

Hiromi URAMOTO, Keizo UMEGAKI, Yuji KAWASAKI, Tetsuo YAMANE, Takatoshi ESASHI
1996 Journal of Nutritional Science and Vitaminology  
The influence of non-purified and AIN purified diets on the development of hypertension was examined in deoxycorticosterone ace tate (DOCA)-salt hypertensive rats and SHRs. For DOCA-salt hyperten sive rats, the development of hypertension was slower in rats fed the AIN 76-purified diet than in those fed the non-purified diet throughout the experimental period of about five weeks. In an experiment using spontan eously hypertensive rats (SHRs), 4-week-old rats were fed either a non purified diet,
more » ... non purified diet, a AIN76-purified diet or a AIN93G-purified diet for about nine weeks. In the first 1-2 weeks, the blood pressure was lower in the SHRs fed the AIN93G-purified diet than in those fed the non-purified diet. However, no significant difference in blood pressure was observed within the SHR group thereafter. Key Words AIN-purified diet, non-purified diet, hypertension, sponta neously hypertensive rats (SHR), DOCA-salt hypertensive rats, blood pressure Hypertension is an important risk factor in cerebral and cardiovascular diseases. It would therefore be of interest to clarify the dietary factors involved in the regulation of blood pressure. To evaluate factors involved in regulating blood pressure, many experiments have been performed using hypertensive rats such as spontaneously hypertensive rats (SHRs) and deoxycorticosterone acetate (DOCA)-salt hypertensive rats (1-5). Generally, the effects of dietary factors on blood pressure is mild in comparison with those of drugs. Therefore, in designing blood pressure experiments dealing with dietary factors, it is important to select a suitable experimental diet. Two types of rodent diets, non-purified commercial diet and American Insti
doi:10.3177/jnsv.42.479 fatcat:5yz6mej5bfaj5phwkoo6ccq3n4