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The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
2017
Nature Communications
The polypeptide GalNAc-transferases (GalNAc-Ts), that initiate mucin-type O-glycosylation, consist of a catalytic and a lectin domain connected by a flexible linker. In addition to recognizing polypeptide sequence, the GalNAc-Ts exhibit unique long-range N-and/or Cterminal prior glycosylation (GalNAc-O-Ser/Thr) preferences modulated by the lectin domain. Here we report studies on GalNAc-T4 that reveal the origins of its unique N-terminal long-range glycopeptide specificity, which is the
doi:10.1038/s41467-017-02006-0
pmid:29208955
pmcid:PMC5716993
fatcat:5im2l7darfgkhnwsse2e5zvb6i