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Sphingosine Kinase 2 Is a Nuclear Protein and Inhibits DNA Synthesis
Journal of Biological Chemistry
Sphingosine kinase-1 (SPHK1) is a key enzyme catalyzing the formation of an important bioactive lipid messenger, sphingosine 1-phosphate, and is implicated in the regulation of cell proliferation and antiapoptotic processes. Biological features of another isozyme SPHK2, however, remain unclear. The present studies were undertaken to characterize SPHK2 by comparison with SPHK1. When SPHK2 was transiently expressed in various cell lines, it was localized in the nuclei as well as in the cytosol,doi:10.1074/jbc.m306577200 pmid:12954646 fatcat:s3dbhsf7jravfbbqt4njqdohkm