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Structural effects driven by rare point mutations in amylin hormone, the type II diabetes associated peptide
[article]
2021
bioRxiv
pre-print
AbstractAmylin is a 37 amino acid peptide hormone co-secreted with insulin, which participates in the glucose homeostasis. This hormone is able to aggregate in a β-sheet conformation and deposit in islet amyloids, a hallmark in type II diabetes. Since amylin is a gene encoded hormone, this peptide has variants caused by single nucleotide polymorphisms (SNPs) that can impact its functions. The effect of these variants can be evaluated by means of computational tools, such as molecular dynamics
doi:10.1101/2021.02.17.431675
fatcat:hywqfiaumjgdbkdkfxt6vpbi7a