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MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic α Cells In Vivo
Molecular and Cellular Biology
The MafB transcription factor is expressed in pancreatic α and β cells during development but becomes exclusive to α cells in adult rodents. Mafb -null ( Mafb −/− ) mice were reported to have reduced α- and β-cell numbers throughout embryonic development. To further analyze the postnatal function of MafB in the pancreas, we generated endocrine cell-specific ( Mafb Δ Endo ) and tamoxifen-dependent ( Mafb Δ TAM ) Mafb knockout mice. Mafb Δ Endo mice exhibited reduced populations ofdoi:10.1128/mcb.00504-17 pmid:29378833 fatcat:5r3jjus6abcgtpc75ysl6eii7e