Cell Swelling-induced Peptide Hormone Secretion

Vladimír Štrbák
2011 Cellular Physiology and Biochemistry  
Cell volume changes induced in various ways (anisosmotic environment, hormones, oxidative stress, substrate uptake) are an integral part of a signal transduction network regulating cell function. 1, 2, 3 Cell swelling has received increasing attention as a stimulus for a variety of intracellular phenomena. 4 One of the most remarkable effects of cell swelling is its powerful effect in inducing exocytosis of material in intracellular secretory vesicles. Secretion of essentially all so-packaged
more » ... rmones 5-24 including those from hypothalamus (thyrotropin-releasing hormone, TRH; gonadotropin-releasing hormone, GnRH), pituitary (LH, FSH, ACTH, MSH, TSH, prolactin, beta endorphin), pancreas (insulin, somatostatin, glucagon), heart (atrial natriuretic hormone) and kidney (renin) are stimulated in a concentration-related manner by medium hyposmolarity or isosmolar medium containing permeant molecules such as ethanol or urea (reviewed in Ref. 21). Cell swelling-induced exocytosis is not restricted to endocrine cells and hormones; medium hyposmolarity also induces secretion of exocrine pancreatic enzymes 5 and myeloperoxidase from human polymorphonuclear leukocytes. 25
doi:10.1159/000335849 pmid:22179004 fatcat:65nkzpdqszbktf6s6kwfdkkkhq