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Circulating Tumor Cells (CTC) are rare cells originated from tumors that travel into the blood stream, extravasate to different organs of which only a small fraction will develop into metastasis. The presence of CTC enumerated with the CellSearch system is associated with a relative short survival and their continued presence after the first cycles of therapy indicates a futile therapy in patients with metastatic carcinomas. Detailed characterization of CTC holds the promise to enable thedoi:10.3390/cancers5041619 pmid:24305653 pmcid:PMC3875957 fatcat:e4gt4ggzzzcl3ihh74q2tufx2u