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Evidence from murine models and human post-mortem studies indicates that monoaminergic nuclei undergo degeneration at the pre-symptomatic stage of Alzheimer's disease (AD). Analysing 129 datasets from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and relying on the Clinical Dementia Rating as group-defining instrument, we hypothesised that the MRI signal of monoaminergic nuclei would be a statistically significant predictor of memory decline in participants initially recruited in ADNIdoi:10.1038/s41598-020-71368-1 pmid:33127923 fatcat:3lmjrbflove6nafx3rz2uaj77u