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Deep Mutational Scanning of Viral Glycoproteins and Their Host Receptors
2021
Frontiers in Molecular Biosciences
Deep mutational scanning or deep mutagenesis is a powerful tool for understanding the sequence diversity available to viruses for adaptation in a laboratory setting. It generally involves tracking an in vitro selection of protein sequence variants with deep sequencing to map mutational effects based on changes in sequence abundance. Coupled with any of a number of selection strategies, deep mutagenesis can explore the mutational diversity available to viral glycoproteins, which mediate critical
doi:10.3389/fmolb.2021.636660
pmid:33898517
pmcid:PMC8062978
fatcat:cyg7ot5j3fgxzi56cgxbog7yhy