Synthesis, Characterization, DNA Binding and Cytotoxic Studies of Platinum(II) and Palladium(II) Complexes of the 2,2'-Bipyridine and an Anion of 1,1-Cyclobutanedicarboxylic Acid

Hassan MANSURI-TORSHIZI, Saeid GHADIMY, Niloofar AKBARZADEH
2001 Chemical and pharmaceutical bulletin  
Two neutral complexes of formula [M(bpy)(cbdca)] [where M is palladium(II) (Pd(II)) or platinum(II) (Pt(II)), bpy is 2,2-bipyridine and cbdca is anion of 1,1-cyclobutanedicarboxylic acid] have been synthesized. These water soluble complexes have been characterized by chemical analysis and conductivity measurements as well as 1 H-NMR, ultraviolet-visible and infrared spectroscopy. In these complexes the ligand cbdca coordinates to Pt(II) or Pd(II) as bidentate with two oxygen atoms. They are
more » ... atoms. They are nonelectrolyte in conductivity water. These complexes inhibit the growth of P 388 lymphocytic leukemia cells and their targets are DNA. They invariably show ID 50 values less than cisplatin. [Pt(bpy)(cbdca)] and [Pd(bpy)(cbdca)] have been interacted with calf thymus DNA and bind to DNA through coordinate covalent bond. In addition, the influence of binding of these complexes on the intensity of EtBr-DNA have been studied. They bind to DNA via a nonintercalating mode.
doi:10.1248/cpb.49.1517 pmid:11767068 fatcat:kd6umxpbhfhxhdpljtm5ypkzdu