Hepatoprotective Effect of Andrographis Paniculata against Oxidative Damage Caused by Cisplatin in Rats

T. Rajendrakumar, Suguna Rao, M. L. Satyanarayana, H. D. Narayanaswamy, S. M. Byregowda, N. B. Shridhar
2020 International Journal of Current Microbiology and Applied Sciences  
The role of ethanolic extract of Andrographis paniculata (AP), in preventing cisplatin (CP) induced oxidative damage in rat liver was studied. The study included 60 Wistar albino rats were divided into 12 rats in each group. Group I served as normal control group. To group II rats, CP was administered at 7.5mg/kg body weight intraperitoneally for single dose. Rats in group III were administered AP at the dose of 500mg/kg body weight for 45 days. Group IV rats were pre-treated with AP 15 days
more » ... or to CP administration and followed by AP treatment for 45 days. Rats in group V were administered with CP and concurrently treated with AP extract at 500mg/kg by oral gavaging for 45 days. The liver samples collected at 7 th , 14 th , 28 th , and 45 th day of the study were subjected for estimation of endogenous antioxidant enzymes (SOD, CAT and GPx) and malondialdehyde (MDA). Significant decrease (P<0.05) in the levels of antioxidant enzymes and increase in MDA levels were recorded in CP treatment group. The AP treatment groups revealed a significant recovery (P<0.05) all enzymes and decrease in MDA levels which suggested that AP has a good antioxidant effect and could be effectively used for prevention of toxic side effects of CP. K e y w o r d s Cisplatin, antioxidants, hepatotoxicity, Andrographis paniculata, Malondialdehyde
doi:10.20546/ijcmas.2020.902.117 fatcat:5lmedevmyfcxla3wkwdrdv3ttu