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We investigated whether curcumin, a chemopreventive agent, inhibited chenodeoxycholate (CD)-or phorbol ester (PMA)-mediated induction of cyclooxygenase-2 (COX-2) in several gastrointestinal cell lines (SK-GT-4, SCC450, IEC-18 and HCA-7). Treatment with curcumin suppressed CD-and PMA-mediated induction of COX-2 protein and synthesis of prostaglandin E 2 . Curcumin also suppressed the induction of COX-2 mRNA by CD and PMA. Nuclear run-offs revealed increased rates of COX-2 transcription afterdoi:10.1093/carcin/20.3.445 pmid:10190560 fatcat:kqxst2k4lvhr5kgwjrpixhonna