Association of 25 OH-Vitamin D and hs-CRPin adults with Essential Hypertension

M Prasad, P Aruna, D Rajeswari, K Ramalingam, J Naidu, Head
International Journal of Clinical Biochemistry and Research   unpublished
Essential hypertensionis a typical example of complex, multifactorial trait and a well studied risk factor for cardiovascular disease. hs-CRP is well known marker of inflammation resulting in atherosclerosis and cardiovascular disease. Recent studies showed that 25-OH-vitamin-D has ananti-inflammatory role and decreased levels may increase the cardiovascular risk in subjects with essential hypertension. The study included 30 adults both male and female with essential hypertension (Systolic
more » ... sion (Systolic Blood Pressure ≥ 140 mm Hg and Diastolic Blood Pressure ≥ 90 mm Hg) as cases. 30 age and sex matched healthy individuals both male & female between the age group of 24-60 years attending General OPD, General Medicine Department, NMCH, were taken as controls. The inverse relationship of Vitamin D with hs-CRP levels leads to cardiovascular risk in subjects with essential hypertension. Essential hypertension is a systemic hypertension of unknown cause. It results from dysregulation of normal homeostatic control mechanisms of blood pressure in the absence of detectable known secondary causes over 95%. Vitamin D3 is synthesized in the skin from cholesterol under the action of ultraviolet B light. (1) Furthermore, Vit D can be ingested as cholecalciferol (vitamin D) or ergocalciferol (Vitamin D2). Vitamin D is subsequently converted to 25-Hydroxy Vitamin D (calciferol) in the liver or stored in adipose tissue. In the kidney, 25-OHVitamin D is converted to 1,25 dihydroxy Vitamin D (calcitriol), which is the biologically active form of Vitamin D. (2) Present research carried out over recent decades indicates that Vitamin D deficiency plays an important role in many causes incresed inflammation and hypertension. (3) High sensitive C-reactive protein (hs-CRP) is acute phase protein which is described as sensitive systemic marker of inflammation and tissue damage especially in Cardio Vascular disease (CVD). (4) Vitamin D being a potent endocrine suppressor of renin biosynthesis as demonstrated in recent studies plays an important role in the regulation of the Renin Angiotensin System. (5) Renin Angiotensin System is one of the several mechanisms that exist to reduce the blood pressure by Vitamin D. (6) Some studies stated an inverse relationship of plasma Vitamin D levels with plasma renin activity in individuals with normal and high blood pressure. (7) Another study stated that, vitamin D had a great influence on diastolic blood pressure than systolic blood pressure. Vitamin D also plays a very important role in inflammation, there by leading to progression of atherosclerosis and blood pressure. (8) Randomized placebo controlled trailsshowed that hs-CRP levels were significantly reduced in vitamin D supplementation group. (9,10)