Back to EGF+61 genetic polymorphisms and lung cancer risk: looking to the future!

Ramon Andrade De Mello
2012 São Paulo Medical Journal  
Dear Editor, Recently, studies in the field of epidermal growth factor (EGF) +61A/G polymorphisms have shown their relevance in relation to cancer behavior. The role of EGF+61 genotypes has been determined in relation to several types of cancer, such as gliomas, gastric cancer and colorectal cancer (CRC). In 2011, it was demonstrated that these polymorphisms could also serve as predictive biomarkers for CRC patients treated with cetuximab. 1 In relation to lung cancer, controversy continues to
more » ... urround the results. 2-4 Thus, the purpose of this letter is to provide a point of view and discuss relevant issues within this framework, focusing on a Portuguese study 4 that contrasts with previous Asian studies 2,3 published in the literature. EGF+61 POLYMORPHISM AND LUNG CANCER Since the last decade, EGF+61A/G polymorphisms have been studied as a risk factor for cancer. 5 e first article published showing this association was on malignant melanoma.
doi:10.1590/s1516-31802012000600011 pmid:23338741 pmcid:PMC10522317 fatcat:efh3nd67jzbphjuc3kvqs4qnue