Tissue acidosis: role in sustained arteriolar dilatation distal to a coronary stenosis

H Gewirtz, G Weeks, M Nathanson, B Sharaf, F Fedele, A S Most
1989 Circulation  
coronary circulation to sustained changes in either myocardial oxygen supply or demand.16-18 Thus, coronary vasodilation is maintained during sustained isoproterenol infusion even though adenosine release by the myocardium peaks rapidly during the initial phase of the infusion and then returns to control levels.16 In addition, adenosine deaminase inhibits, in part, the initial flow increase observed in response to isoproterenol but has no effect on the sustained flow response to the drug.'7 The
more » ... concentration of potassium ion also has increased in coronary venous blood in response to vasodilation stimuli (e.g., pacing and ischemia) and then returned to control levels even though coronary vasodilation persists. 18 Whether or not similar changes occur in coronary venous pH and Pco2 by guest on July 23, 2018 http://circ.ahajournals.org/ Downloaded from response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis. Circulation 1988; 78:729-735 32. Ruocco NA Jr, Most AS, Sasken H, Steiner M, Gewirtz H: The role of endogenous prostacyclin in myocardial blood flow regulation distal to a severe coronary stenosis. Cardiovasc Res 1988;22:511-519 KEY WORDS * coronary flow regulation * pH Pco2 coronary flow * maintenance of arteriolar dilation by guest on
doi:10.1161/01.cir.79.4.890 pmid:2924419 fatcat:wqrm6lptijeljabvqotqhcrufm