Hepatobiliary fibrinolysis in experimental cirrhotic rats

Toyohiko ARIGA, Yumiko IKEDA, Masahiko NATORI, Jun KATOH, Yasuharu OHIRA, Hideo IMAI, Hiroko SAWAI, Eiji ENDOH, Susumu OSHIBA
1987 Blood & Vessel  
We found that there was an antigen common to the biliary plasminogen activator, bilokinase (BK) in hepatocytes by histochemical and immunological studies. It was also demonstrated that the cultured hepatocytes excreted a plasminogen activator into the medium. These observations suggest that there is close relation between hepatic and biliary fibrinolytic systems. The present study was carried out to clarify whether a pathological state of liver affects to biliary fibrinolysis. Cirrhosis was
more » ... uced in rats by the methods of Tanner et al. and McLean et al. with some modifications. The cirrhosis was raised at 5 week period, showing 2 times increased level of proline and marked development of collagen fibers in the liver tissues. Of the parameters measured, fibrinogen was found to be elevated significantly. PT and APTT were slightly shortened and ELT tended to prolongation. Fibrinolytic autography showed clear lysis areas at the sites corresponding to the biliary canaliculi. BK activity in bile was higher in the cirrhotic rats than of control rats. Thus, dynamics of BK might change in association with the pathophysiology of the liver.
doi:10.2491/jjsth1970.18.286 fatcat:pm533mhwlvf6vky3fp7m55chre