The author obtained the following results concerning the content of urinay 17-KS in various kinds of internal diseases. 1) In diabetes mellitus it is normal or decreases, but some cases show an increased content. 2) In Basedow's disease it is normal or decreases, and in myxodema it decreases, but it returns to normal content as the basal metabolism becomes normal. 3) In addison's disease it decreases, but by no means becomes zero. In addisonism, it decreases too. 4) In various sorts of anemia

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... decreases, but it is normal in minimal cases of anemia. In leukemia it decreases. 5) In liver diseases it generally decreases. 6) In heart diseases, cases without decompensation show a normal content and cases with decompensation showa decreased content, but the content increases with emeliorated decompensation.