، ‫اسالهي‬ ‫گيلدا‬ 5 ‫زًدی‬ ‫ٌّگاهِ‬ ، * 9 ‫فرٌّگ‬ ‫آرهيي‬ ، 4 ‫ٍکيلي‬ ‫هحوَد‬ ، 2 ‫هحودی‬ ‫ًسين‬ ، 1 ‫بٌادکَکي‬ ‫دّقاى‬ ‫اهيي‬ ، 7 ‫چكيدُ‬ ‫هقدهِ:‬ ‫قالبي‬ ‫هصطفي‬ ‫ّوكار‬ ٍ ‫اى‬ 5  ‫يسد‬ ‫صدٍقي‬ ‫شْيد‬ ‫درهاًي‬ ‫ـ‬ ‫بْداشتي‬ ‫خدهات‬ ٍ ‫پسشكي‬ ‫علَم‬ ‫داًشگاُ‬ ‫هجلِ‬ ‫دٍرُ‬ 52 ‫شوارُ‬ ، References: 1-Wieczorek P, Sacha P, Hauschild T, Zórawski M, Krawczyk M, Tryniszewska E. Multidrug resistant Acinetobacter baumannii-the role of AdeABC (RND family) efflux pump in resistance to antibiotics.

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... ia Histochem Cytobiol 2008; 46(3): 257-56. ‫قالبي‬ ‫هصطفي‬ ‫ّوكار‬ ٍ ‫اى‬ 7  ‫يسد‬ ‫صدٍقي‬ ‫شْيد‬ ‫درهاًي‬ ‫ـ‬ ‫بْداشتي‬ ‫خدهات‬ ٍ ‫پسشكي‬ ‫علَم‬ ‫داًشگاُ‬ ‫هجلِ‬ ‫دٍرُ‬ 52 ‫شوارُ‬ ، 1 ‫فرٍرديي‬ ، 1991 2-Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: emergence of a successful pathogen. Clinic microbiology rev 2008; 21(3): 538-82. EK, et al. Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements. PLoS One 2013; 8(6): e66584. 6-Hsueh PR, Teng LJ, Chen CY, Chen WH, Yu CJ, Ho SW, et al. Pandrug-resistant Acinetobacter baumannii causing nosocomial infections in a university hospital, Taiwan. Emerging infectious diseases 2002; 8(8): 827-32. 7-Mahajan G, Sheemar S, Chopra S, Kaur J, Chowdhary D, Makhija S. Carbapenem resistance and phenotypic detection of carbapenemases in clinical isolates of Acinetobacter baumannii. Indian J Med Sci 2011; 65(1): 18-Abstract Introduction: Acinetobacter baumannii is a non-fermentative gram-negative coccobacill that is prevalent in intensive care units. Carbapenem resistant A.baumannii isolates have been reported worldwide. Oxasillinase beta-lactamase enzymes are involved in bacterial resistance to carbapenem. This study aimed to determine the prevalence of bla OXA-23 and bla OXA-24 genes in A. baumannii isolated from tube discharge specimens of hospitalized patients in the intensive care units of the hospitals in Isfahan, Iran, in 2015. Methods: A total of 40 isolates of A. baumannii were collected from the patients admitted to the intensive care units of the hospitals in Isfahan in 2015, they were identified by biochemical methods and detection of bla OXA-51 like gene. Antibiotic resistance pattern and minimum inhibitory concentration of imipenem were determined using disk diffusion and E-test methods respectively according to CLSI2015 protocol. bla OXA-23 and bla OXA-24 genes were detected by PCR method. Data were analyzed by SPSS (v.16) software and chi-square tests. Results: All isolates were found resistant to ceftazidime, ceftriaxone, meropenem and imipenem and the lowest resistance were seen against colistin (0%) and tigecycline (10%), respectively. All isolates were resistant to imipenem using Etest method with MIC ≥ 32 μg / ml. bla OXA-23 and bla OXA-24 genes were detected in 87.5% and 25% of isolates, respectively. Conclusion: Due to the results, treatment of A. baumannii isolates by carbapenems is ineffective and tigecycline or colistin could be used for treatment. Other studies for detection of other mechanisms for carbapenem resistance are recommended.