Structure and Function of Fbxo7/PARK15 in Parkinson's Disease

Suzanne J. Randle, Heike Laman
2017 Current protein and peptide science  
Fbxo7/PARK15 has well-defined roles, acting as part of a Skp1-Cul1-F box protein (SCF)-type E3 ubiquitin ligase and also has SCF-independent activities. Mutations within FBXO7 have been found to cause an early-onset Parkinson's disease, and these are found within or near to its functional domains, including its F-box domain (FBD), its proline rich region (PRR), and its ubiquitin-like domain (Ubl). We highlight recent advances in our understanding of Fbxo7 function in Parkinson's disease, with
more » ... spect to these mutations and where they occur in the Fbxo7 protein. We hypothesize that many of Fbxo7 functions contribute to its role in PD pathogenesis.
doi:10.2174/1389203717666160311121433 pmid:26965690 fatcat:aka5txcu2vaknljvnujqq7iaii