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α-arrestins are a family of proteins that are implicated in multiple Background: biological processes, including metabolism and receptor desensitization. Here, we sought to examine the roles of α-arrestins in the longevity Methods: of through an RNA interference screen. Caenorhabditis elegans We found that knocking down each of 24 out of total 29 Results: C. elegans α-arrestins had little effect on lifespan. Thus, individual α-arrestins C. elegans may have minor effects on longevity. This studydoi:10.12688/f1000research.12337.3 pmid:29123644 pmcid:PMC5657022 fatcat:qitsnksklrhsvf6jdhjyhfty5a