Click To Bind: Microwave-Assisted Solid-Phase Synthesis of Peptoids Incorporating Pyridine–Triazole Ligands and Their Copper(II) Complexes

Galia Maayan, Tamar Zabrodski, Maria Baskin, Prathap Kaniraj
2014 Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry  
We describe a fast and efficient incorporation of the ligands 2-(1H-1,2,3-triazol-4-yl)pyridine and 2-(1H-1,2,3-triazol-1-ylmethyl)pyridine into N-substituted glycine peptoid oligomers by the azidealkyne cycloaddition (click) reaction on a solid support under microwave irradiation. Peptoids bearing these ligands formed stable complexes with copper(II).
doi:10.1055/s-0034-1378938 fatcat:7lftvt263fax7am2yuakuxbb44