Anti-oxidative potentials of some medicinal plants on lipid peroxidation in alloxan-induced diabetic rats

Ajiroghene S. GOMETI,, Victor N. OGUGUA,, Parker E. JOSHUA,, Christian E. ODO,, Florence O. NDUKA,, Innocent O. ORHONIGBE,
2014 African Journal of Biotechnology  
Diabetes mellitus is a metabolic disease characterized by hyperglycemia and if not properly controlled, culminates in increased oxidative stress and decrease in anti-oxidant levels. The leaves of Psidium guajava, Anacardium occidentale, Eucalyptus globulus and fruits of Xylopia aethiopica are used in the management of diabetes mellitus and thus, their anti-oxidative effects in alloxan-induced diabetes mellitus in Wister albino rats were investigated using standard methods. The administration of
more » ... e administration of P. guajava, A. occidentale, E. globulus leaf and X. aethiopica fruit extracts caused significant (p<0.05) increases in the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and vitamin C concentration. These increases in some test groups were not significantly (p>0.05) different from those of the glibenclamide groups, with others better increased than the glibenclamide groups. Malondialdehyde (MDA) concentration was significantly (p<0.05) reduced in all the groups except the diabetic-untreated group that showed a marked increase attesting to the fact that peroxidative activity occurred after the induction of diabetes mellitus. In conclusion, the above plants demonstrated anti-oxidative effects and therefore, may be used in the amelioration of disorders associated with oxidative stress.
doi:10.5897/ajb2013.13297 fatcat:2ae5voxydbfevkujnozcull66q