Is Hydroxychloroquine a Safe and Effective Choice for Covid-19 Prophylaxis

Rodrigo Mois�s de Almeida-Leite, Tais Rondello Bonatti, Carolina Rodrigues Ponzoni, Ana Cristina da Cunha Korndorfer, Solange Bifani Tavares da Silva
2020 American Journal of Infectious Diseases  
The authors speculate about the possibility of Hydroxychloroquine as Covid-19 Phrophylaxis in the dose of 400 mg per week. The authors compared the experience of Malaria phrophylaxis in this dose, with acceptable safety profile. Also, we compared in vitro susceptibility of SARS-Cov-2 with that of Plasmodium falciparum. This agent show significant higher potency for the first. Also, the extended Halflife (40-50 days) make it an acceptable choice for prophylaxis. We also cite Brazilian experience
more » ... razilian experience with Chloroquinated Salt in the 1950s, its efficacy and feasibility. Lastly, we suggest that clinical trials should be conducted test this hypothesis.
doi:10.3844/ajidsp.2020.118.119 fatcat:qykxbk6xmzd5fakvqdcy77uyk4