Physico-chemical and pharmacological characteristics of mixed ligand complex of Zn(II) with Ranitidine and Glycine

Prachi Arya, Savita Shrivastava, Neha Singh, Sulekh Chandra
2010 Journal of Chemical and Pharmaceutical Research J. Chem. Pharm. Res   unpublished
Mixed ligand complex of Zn(II) with ranitidine as one ligand and glycine as second ligand was prepared. The complex was characterized on the basis of elemental analysis, electronic and IR spectral and particle size measurements. Pharmacological effects of the complex on gastric secretion in pylorous ligated rats and gastric emptying rate in albino rats were also studied. It was found that the complex in dose range of 200-500 mg/kg produced significant reduction in total and free acid and it had
more » ... no effect on gastric emptying rate. INTRODUCATION Ranitidine (ran) is a histamine H 2-receptor antagonist. The drug has been used in the treatment of duodenal and gastric ulceration [1,2] and is given orally as a tablet as well as in the form of injection. It has been reported by some workers [3,6] that complexation of antiulcer drugs has profound effect on their potency. Therefore, if the mixed ligand metal complexes of ranitidine as one ligand and amino acids which perform diverse biological functions in the body as second ligand, are prepared and probed for their pharmacological effect, the study can be of great use in the treatment of ulcer. Keeping this in view, the complex of Zn(II) with ranitidine as one ligand