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Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila
2002
Development
The restriction of Pipe, a potential glycosaminoglycan-modifying enzyme, to ventral follicle cells of the egg chamber is essential for dorsoventral axis formation in the Drosophila embryo. pipe repression depends on the TGFalpha-like ligand Gurken, which activates the Drosophila EGF receptor in dorsal follicle cells. An analysis of Raf mutant clones shows that EGF signalling is required cell-autonomously in all dorsal follicle cells along the anteroposterior axis of the egg chamber to repress
pmid:12050143
fatcat:6kqmlodp4bhk3hgmo3pvrzawum