Multimodal magnetic resonance imaging investigation of basal forebrain damage and cognitive deficits in Parkinson's disease

Fatma Gargouri, Cécile Gallea, Marie Mongin, Nadya Pyatigorskaya, Romain Valabregue, Claire Ewenczyk, Marie Sarazin, Lydia Yahia‐Cherif, Marie Vidailhet, Stéphane Lehéricy
2018 Movement Disorders  
Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1-2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4).
doi:10.1002/mds.27561 pmid:30536444 pmcid:PMC6590238 fatcat:h3yfzjasejdmxjpdqftfohzjgm