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A Comparison of 15% Azelaic Acid Gel and 0.75% Metronidazole Gel in the Topical Treatment of Papulopustular Rosacea

Boni E. Elewski, Alan B. Fleischer, David M. Pariser
2003 Archives of Dermatology  

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Objective: To compare the efficacy and safety of a novel formulation of 15% azelaic acid gel (Finacea; Berlex Laboratories, Inc, Montville, NJ) with 0.75% metronidazole gel (MetroGel; Galderma Laboratories LP, Fort Worth, Tex) as topical therapy for moderate, papulopustular facial rosacea. Design: Multicenter, double-blind, randomized, parallelgroup study. Setting: Thirteen US centers. Patients: A total of 251 patients with papulopustular rosacea with persistent erythema and telangiectasia.
more » ... rventions: Patients were randomized to receive azelaic acid gel or metronidazole gel twice daily for 15 weeks. Main Outcome Measures: Nominal and percent change in inflammatory lesion count, change in erythema and telangiectasia severity ratings, investigator's global assessment of rosacea, and investigator's and patient's overall improvement ratings.
doi:10.1001/archderm.139.11.1444 pmid:14623704 fatcat:i3ujo6hvpzao3luygr3s4pzvwi
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Boni E. Elewski, Alan B. Fleischer, David M. Pariser. "A Comparison of 15% Azelaic Acid Gel and 0.75% Metronidazole Gel in the Topical Treatment of Papulopustular Rosacea." Archives of Dermatology 139.11 (2003)