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The Soft Metal Ion Binding Sites in theStaphylococcus aureuspI258 CadC Cd(II)/Pb(II)/Zn(II)-responsive Repressor Are Formed between Subunits of the Homodimer
Journal of Biological Chemistry
The Staphylococcus aureus plasmid pI258 CadC is a homodimeric repressor that binds Cd(II), Pb(II), and Zn(II) and regulates expression of the cadAC operon. CadC binds two Cd(II) ions per dimer, with a tetrathiolate binding site composed of residues Cys 7 , Cys 11 , Cys 58 , and Cys 60 . It is not known whether each site consists of residues from a single monomer or from residues contributed by both subunits. To examine whether Cys 7 and Cys 11 are spatially proximate to Cys 58 and Cys 60 of thedoi:10.1074/jbc.m206536200 pmid:12176999 fatcat:l5gyewly4navra6qtewn2l3dki