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UBL4A Augments Innate Immunity by Promoting the K63-Linked Ubiquitination of TRAF6
2019
Journal of Immunology
Human UBL4A/GdX, encoding an ubiquitin-like protein, was shown in this study to be upregulated by viral infection and IFN stimulation. Then the functions of UBL4A in antiviral immune response were characterized. Overexpression of UBL4A promoted RNA virus-induced ISRE or IFN-β or NF-κB activation, leading to enhanced type I IFN transcription and reduced virus replication. Consistently, knockdown of UBL4A resulted in reduced type I IFN transcription and enhanced virus replication. Additionally,
doi:10.4049/jimmunol.1800750
pmid:31451677
fatcat:rl63ikoazjarhlrbohizxx3w3e