Tamsulosin – modified-release and oral-controlled absorption system formulations in the treatment of benign prostatic hyperplasia

Marleen M van Dijk, Jean JMCH de la Rosette, Martin C Michel
2006 Therapy  
Tamsulosin is an α 1 -adrenergic receptor antagonist. For many years, it has been available in a modified-release (MR) capsule formulation only, but recently, an oral-controlled absorption system (OCAS) tablet formulation has been introduced. Tamsulosin is an effective treatment for patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia for many years. The overall tolerability of tamsulosin 0.4 mg MR is comparable to placebo and is not affected by cardiovascular
more » ... morbidity or concomitant medication. The tamsulosin 0.4 mg OCAS tablet has a smoothened pharmacokinetic profile compared with the 0.4 mg MR capsule. While the efficacy of tamsulosin OCAS and tamsulosin MR are comparable, the OCAS formulation appears to have minor advantages regarding tolerability, which may become clinically relevant if the MR capsule is taken on an empty stomach.
doi:10.2217/14750708.3.2.237 fatcat:42wue3z2kzamddisfjoyv4iiye