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DNA repair targeted therapy: The past or future of cancer treatment?
2016
Pharmacology and Therapeutics
The repair of DNA damage is a complex process that relies on particular pathways to remedy specific types of damage to DNA. The range of insults to DNA includes small, modest changes in structure including mismatched bases and simple methylation events to oxidized bases, intra-and interstrand DNA crosslinks, DNA double strand breaks and protein-DNA adducts. Pathways required for the repair of these lesions include mismatch repair, base excision repair, nucleotide excision repair, and the
doi:10.1016/j.pharmthera.2016.02.003
pmid:26896565
pmcid:PMC4811676
fatcat:b4sz6w4gwfegrapnfjszinremq