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RhoA signaling in phorbol ester-induced apoptosis
2006
Journal of Biomedical Science
Exposure of cells to phorbol ester activates protein kinase C (PKC) to induce apoptosis or differentiation, depending on the cellular context. In erythroblastic cell lines, TF-1 and D2, upregulation of the RhoA signaling promotes phorbol ester-induced apoptosis through activating Rho-associated kinase (ROCK)/ phosphorylation of myosin light chain (MLC), thus generating membrane contraction force. As a result, cell adhesion is inhibited and death receptor-mediated death pathway is activated in
doi:10.1007/s11373-005-9056-4
pmid:16496227
fatcat:ceqnliethvhl7njfxwor4dj3qm