Systems chemical biology and the Semantic Web: what they mean for the future of drug discovery research

David J. Wild, Ying Ding, Amit P. Sheth, Lee Harland, Eric M. Gifford, Michael S. Lajiness
2012 Drug Discovery Today  
Systems chemical biology, the integration of chemistry, biology and computation to generate understanding about the way small molecules affect biological systems as a whole, as well as related fields such as chemogenomics, are central to emerging new paradigms of drug discovery such as drug repurposing and personalized medicine. Recent Semantic Web technologies such as RDF and SPARQL are technical enablers of systems chemical biology, facilitating the deployment of advanced algorithms for
more » ... ing and mining large integrated datasets. In this paper, we aim to demonstrate how these technologies together can change the way that drug discovery is accomplished.
doi:10.1016/j.drudis.2011.12.019 pmid:22222943 fatcat:ihung2o5cnhrjbytslxfm2lxx4