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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects selected cortical and spinal neuronal populations, leading to progressive paralysis and death. A growing body of evidences suggests that the disease may originate in the cerebral cortex and propagate in a corticofugal manner. In particular, transcranial magnetic stimulation studies revealed that ALS patients present with early cortical hyperexcitability arising from a combination of increaseddoi:10.3389/fnins.2020.00363 pmid:32410944 pmcid:PMC7201269 fatcat:66cevdajb5bkrjhd3mcxbr5ssa