Case Report The administration of antibiotics by injection may have some consequences as loco regional reactions ranging from skin necrosis at the injection site to acute limb ischemia. The observations of three patients with acute upper limb ischemia following accidental intra-arterial antibiotic injection with coldness, cyanosis, suppression of radial and ulnar pulses and necrosis of the extremities are presented there. Enoxaparin-based heparin therapy was initiated with very good results.

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... ough these observations, and after a review of the literature, the pathophysiological mechanisms and therapeutic means will be reminded.